Allergy Testing - Book an appointment online Allergy Testing Survey
Book an appointment online Request an allergy test Register as a new patient


London Allergy & Immunology Centre

Hay Fever & Allergic Rhinitis

Seasonal & Pollen-Related Allergic Rhinitis — Diagnosis, Treatment & Immunotherapy

Expert private care aligned with the ARIA 2022 guidelines, BSACI rhinitis guideline, and current EAACI immunotherapy evidence. Molecular pollen testing, SLIT tablets, and SCIT available at Harley Street, City & East London.

1 in 4

UK adults affected

Mar–Oct

UK pollen season

Up to 80%

Have asthma link

3–5 yrs

Immunotherapy course

Disease-modifying

Only AIT changes the cause

What Is Hay Fever (Allergic Rhinitis)?

Seasonal allergic rhinitis — commonly called hay fever — is an IgE-mediated hypersensitivity condition in which the nasal mucosa, eyes, and upper airways become inflamed on exposure to airborne pollen. It affects approximately 1 in 4 adults and 1 in 5 children in the UK, making it one of the most prevalent allergic conditions in the country.

When sensitised individuals inhale pollen, allergen proteins bind to IgE antibodies on mast cells, triggering histamine release and causing the immediate-phase response (sneezing, itch, rhinorrhoea) within minutes. A late-phase response 4–8 hours later drives persistent congestion and mucosal inflammation.

Seasonal vs Perennial

Seasonal rhinitis is driven by outdoor allergens with a defined season (tree pollens, grass, weeds, outdoor moulds). Perennial rhinitis is year-round, typically caused by house dust mite, cat, or dog. Many patients have both.

Quality of Life Impact

Allergic rhinitis impairs sleep, concentration, and productivity significantly. It causes school absences, reduced academic performance in children, and is linked to impaired driving performance. Up to 80% of asthma patients also have allergic rhinitis — and poorly controlled rhinitis worsens asthma.

Main UK Pollen Triggers

  • Grass pollen — most common UK trigger (May–Jul)
  • Birch pollen — major spring trigger; causes oral allergy syndrome
  • Weed pollens — mugwort, plantain, nettle (Jul–Sep)
  • Outdoor moulds — Alternaria (Aug–Oct)

UK Pollen Calendar — When Do Pollens Peak?

Understanding when your specific pollen peaks helps predict symptom timing and plan treatment. Warmer, earlier springs (increasingly common with climate change) can advance tree pollen by 2–4 weeks.

Allergen Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
Hazel
Alder ●●
Birch ★ ●●●
Oak / Plane ●●
Grass ★★ ●● ●●● ●●●
Mugwort / Nettle ●●
Alternaria / Moulds ●● ●●

★ Birch: also causes oral allergy syndrome to raw apples, hazelnuts, stone fruits. ★★ Grass: most common UK trigger. Timing varies; check the Met Office pollen forecast for real-time data.

Climate change: The UK pollen season is lengthening. Warmer winters advance tree pollen by 2–4 weeks. Higher atmospheric CO₂ increases pollen production and allergenicity. Earlier treatment initiation and longer immunotherapy seasons are increasingly important.

Symptoms & ARIA Severity Classification

Nasal

  • Repeated sneezing
  • Watery or mucoid runny nose
  • Nasal congestion / blockage
  • Itchy nose

Eyes (Allergic Conjunctivitis)

  • Red, watery, itchy eyes
  • Usually bilateral
  • Swollen eyelids
  • Light sensitivity

Associated

  • Itchy throat, palate, or ears
  • Headache / facial pressure
  • Fatigue and poor sleep
  • Worsening asthma on high pollen days

ARIA Severity & Persistence Classification

Duration Severity Definition First-Line Treatment
Intermittent Mild Symptoms <4 days/week or <4 weeks. Sleep and daily activities unaffected. Oral or intranasal antihistamine. INCS if nasal blockage.
Intermittent Moderate–Severe Symptoms <4 days/week but impairing sleep or daily activities. Intranasal corticosteroid + antihistamine.
Persistent Mild Symptoms ≥4 days/week AND ≥4 weeks, but not significantly impairing life. Intranasal corticosteroid + regular antihistamine. Review at 2–4 weeks.
Persistent Moderate–Severe Symptoms ≥4 days/week AND ≥4 weeks AND impairing sleep, work or school. INCS + antihistamine. Consider allergen immunotherapy. Specialist referral.

Oral Allergy Syndrome (Pollen–Food Allergy Syndrome)

Oral allergy syndrome (OAS) occurs in pollen-sensitised individuals when raw foods containing structurally similar proteins are eaten. The immune system cross-reacts, causing immediate tingling, itching, or mild swelling of the lips, mouth, and throat. Symptoms typically resolve within minutes and cooked versions of the same food are usually tolerated as heat destroys the cross-reactive proteins.

Birch Pollen Cross-Reactions (Bet v 1)

Most common UK pollen–food syndrome:

  • Fruits: raw apple, pear, cherry, plum, peach, apricot
  • Nuts: raw hazelnut (Cor a 1), almond
  • Vegetables: raw carrot, celery, parsley
  • Soya (Gly m 4)

Grass Pollen Cross-Reactions

Grass-sensitised patients may react to:

  • Peach, melon, tomato, kiwi
  • Wheat via profilins (not true wheat allergy)

Grass pollen AIT can reduce OAS symptoms in grass cross-reactive patients.

When to Seek Testing

Most OAS is mild, but a small minority — particularly those sensitised to heat-stable LTP allergens (e.g. Pru p 3 in peach) or Ara h 2 — can have systemic reactions. ALEX³ molecular testing identifies whether you have low-risk PR-10 cross-reactivity or a higher-risk sensitisation. ALEX³ information →

Diagnosis & Molecular Pollen Testing

Accurate identification of the specific pollen sensitising you is essential — not just to confirm allergy, but to select the correct immunotherapy allergen. Molecular component testing identifies the specific proteins driving sensitisation.

Skin Prick Testing

First-line, fast, sensitive. Results in 20 minutes. Tests grass, birch, alder, hazel, oak, mugwort, and outdoor moulds. Antihistamines must be stopped 3–7 days before.

Specific IgE Blood Tests

Quantitative sIgE to individual pollen extracts. No antihistamine restriction. Available for 600+ allergens via ImmunoCAP. Useful when SPT is not possible.

ALEX³ Molecular CRD — 300 Components

  • Phl p 1 / Phl p 5 — primary grass allergy; confirm SLIT/SCIT candidacy
  • Bet v 1 — primary birch sensitiser; explains OAS to apples and hazelnuts
  • Profilins (Bet v 2) — low-risk cross-reactive marker
  • Distinguishes primary pollen from CCD cross-reactivity for correct AIT selection

ALEX³ test →

Treatment — ARIA Step-Up Approach

Treatment is escalated based on ARIA severity and response. Starting intranasal corticosteroids 2–4 weeks before the pollen season significantly improves their effectiveness.

1

Intranasal Corticosteroids (INCS) — First-Line

Most effective single treatment. Best for nasal blockage (which antihistamines do not address). Start 2–4 weeks before pollen season. UK products: fluticasone (Flixonase, Avamys), mometasone (Nasonex), budesonide (Rhinocort). Correct technique (aim away from the septum) is essential for efficacy.

2

Second-Generation Antihistamines — For Sneezing, Itching & Rhinorrhoea

Non-sedating oral antihistamines taken daily throughout the season. UK options: cetirizine 10 mg, loratadine 10 mg, fexofenadine 120–180 mg, desloratadine 5 mg. Do not use first-generation antihistamines (chlorphenamine) — they impair driving and concentration.

3

Intranasal Antihistamine / Combination Spray

Azelastine nasal spray acts within 15 minutes. Available as a combination product (INCS + azelastine, e.g. Dymista®) with evidence of superiority for moderate–severe rhinitis. For allergic conjunctivitis: antihistamine eye drops (azelastine, ketotifen) or sodium cromoglicate 2% drops.

4

Leukotriene Antagonists (Montelukast) — Add-On for Rhinitis + Asthma

Useful in patients with both rhinitis and asthma. Less effective than INCS alone for rhinitis. MHRA 2020 guidance: discuss neuropsychiatric side effects with patients before prescribing.

5

Short-Course Oral Corticosteroids — Last Resort for Severe Exacerbations

A short course of oral prednisolone (5–7 days) may be considered for severe, incapacitating rhinitis during peak season when other treatments have failed. Not for routine use — maximum once or twice per year due to systemic steroid risks.

Still not controlled despite step 3? This is the point at which allergen immunotherapy (AIT) should be considered. AIT addresses the underlying cause and provides long-term disease-modifying benefit. See below.

ENDOFFILE

Allergen Immunotherapy (AIT) — The Only Disease-Modifying Treatment

Allergen immunotherapy (AIT) is the only treatment that modifies the underlying allergic disease. By gradually introducing the allergen, AIT re-programmes the immune system — reducing IgE-mediated responses, inducing regulatory T cells, and producing blocking IgG4 antibodies. Benefits persist for years after completing the course — unlike pharmacotherapy which only suppresses symptoms while being taken.

Sublingual Immunotherapy (SLIT) — Tablets or Drops

SLIT tablets are the most widely used form of pollen AIT in the UK. Placed under the tongue daily at home. UK-licensed products:

  • Grazax® (grass pollen SLIT tablet, ALK) — licensed adults and children ≥5 years
  • Itulazax® (tree pollen / birch SLIT tablet, ALK) — licensed for birch-allergic adults
  • Sublingual drops — available for multiple pollens where tablets are not licensed

First dose given under medical supervision. Minimum course: 3 years. Start at least 4 months before the pollen season for best effect.

Subcutaneous Immunotherapy (SCIT) — Allergy Injections

Injections of purified pollen extract in clinic, with 30-minute post-injection observation. Preferred when:

  • Multiple pollen sensitivities (combined extracts available)
  • SLIT is not available for the specific allergen
  • SLIT has failed or is not tolerated

Build-up: weekly injections over 3–4 months. Maintenance: every 4–8 weeks for 3–5 years. Available at our London clinics with full resuscitation facilities.

30–40%

Reduction in symptom scores

~50%

Reduced medication use

Durable

Benefits persist years after completing course

Prevents

New sensitisations & progression to asthma

Correct allergen selection is critical: AIT works best when the primary sensitising pollen is correctly identified via molecular testing (Phl p 1/5 for grass, Bet v 1 for birch). Our consultants use ALEX³ CRD to ensure the right product is chosen. Starting in autumn or winter — at least 4 months before the season — allows the build-up phase to be completed before exposure begins.

Reducing Pollen Exposure — Practical UK Advice

Monitoring Pollen

  • Check the Met Office pollen forecast daily
  • Pollen peaks 7–11 am and early evening on warm, breezy days
  • Lower after rain and on cool, overcast days

Outdoors

  • Wear wraparound sunglasses
  • Avoid mowing lawns or long-grass areas
  • Apply petroleum jelly inside nostrils
  • Limit outdoor exercise during peak pollen hours

At Home

  • Keep windows closed during high pollen periods
  • Shower and wash hair after being outdoors
  • Dry laundry indoors or use a tumble dryer
  • HEPA air purifiers reduce indoor pollen

Travel & Exams

  • Use car pollen filters; replace annually
  • Coastal destinations have lower pollen counts
  • GCSE / A-level exams coincide with peak grass pollen — plan medication well in advance

Hay Fever in Children

Hay fever is very common in children and adolescents — often underdiagnosed and undertreated. It can significantly impair school attendance, concentration, sleep quality, and exam performance, particularly as the grass pollen season (May–July) coincides with GCSE and A-level examinations.

Treatment in Children

  • Intranasal corticosteroids: safe and effective from age 6 (some from age 2–4)
  • Non-sedating antihistamines: cetirizine, loratadine from age 2
  • Eye drops: sodium cromoglicate safe from any age
  • Grazax® SLIT tablets: licensed from age 5

Exam Season Planning

Book a review in January–February to plan treatment before the season starts. Starting INCS 4 weeks before pollen begins significantly improves outcomes. Consider SLIT tablets for long-term benefit.

AIT in Children

AIT in children can prevent new sensitisations and reduce the risk of developing asthma. Grazax® is licensed from age 5. SCIT from age 6–8 in selected cases. Our paediatric allergy consultants assess suitability individually.

Frequently Asked Questions

My hay fever symptoms start earlier each year. Why?

Warmer winters caused by climate change are advancing tree pollen seasons by 2–4 weeks. If your symptoms now start in February or March, you may be primarily sensitised to early tree pollens (hazel, alder, birch) rather than grass pollen. Molecular pollen testing will identify your specific sensitisation for better-targeted treatment.

I get a tingly mouth eating raw apples. Is this related to my hay fever?

Almost certainly yes — this is oral allergy syndrome caused by birch pollen cross-reactivity (Bet v 1 / Mal d 1). Cooked apple is usually tolerated. Molecular testing is worthwhile to confirm which proteins are involved and whether there is any risk of more significant reactions beyond OAS.

How long does immunotherapy take to work?

Most patients notice meaningful improvement in their first or second pollen season on SLIT. Full benefit develops over 2–3 years. A complete course of 3–5 years provides the most durable long-term effect, with benefits persisting several years after stopping. Starting at least 4 months before the season gives the best results.

Can I have immunotherapy if I also have asthma?

Yes — patients with both allergic rhinitis and mild-to-moderate allergic asthma are good candidates, as AIT can improve both simultaneously. Asthma must be stable and adequately controlled before starting. Poorly controlled or severe asthma is a contraindication to SCIT and requires careful assessment before SLIT. Peak flow is checked before each SCIT injection.

I am positive to both grass and birch. Do I need immunotherapy for both?

Not necessarily. Molecular testing (ALEX³) is essential. Some patients test positive to both on standard tests due to CCD cross-reactivity, but are primarily sensitised to only one pollen. Without CRD, you risk selecting the wrong allergen or undergoing unnecessary additional treatment. Our consultants use ALEX³ to ensure the right immunotherapy product is chosen.

My hay fever is getting worse every year. Is this normal?

Worsening symptoms can result from accumulating additional pollen sensitisations, increasing pollen loads with climate change, or progression from rhinitis to asthma. If antihistamines and INCS no longer provide adequate control, this is the right time for a specialist assessment and consideration of allergen immunotherapy — which can halt and reverse this progression.

Trusted Resources

Met Office Pollen Forecast →

Daily UK pollen count and 5-day forecast by region

ARIA Guidelines →

International Allergic Rhinitis and its Impact on Asthma guidelines

BSACI Rhinitis Guideline →

British Society for Allergy and Clinical Immunology rhinitis guidelines

NICE CKS Allergic Rhinitis →

NICE Clinical Knowledge Summary for allergic rhinitis

Allergy UK →

Patient information on hay fever, pollen allergy, and finding support

ALEX³ Molecular Pollen Testing →

300 allergens including Phl p 1/5, Bet v 1, and all major UK pollen components

Book a Hay Fever & Allergic Rhinitis Assessment

Harley Street | City of London | East London | UK Telemedicine | No GP Referral Required (self-pay)

Allergy/Immunology: 020 314 33449  |  Paediatrics: 020 314 33446  |  ENT: 020 314 33448

Important Notice

This page provides general educational information only and is not a substitute for individual medical advice. All diagnoses and treatment decisions are made by a qualified consultant following full clinical assessment. In a medical emergency, call 999.

References

  1. Bousquet J, Schunemann HJ, Togias A, et al. Next-generation ARIA guidelines for allergic rhinitis based on GRADE and real-world evidence. J Allergy Clin Immunol. 2020;145(1):70–80.
  2. Scadding GK, Kariyawasam HH, et al. BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis. Clin Exp Allergy. 2017;47(7):856–889. Updated 2022.
  3. Pfaar O, Bachert C, et al. Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases. Allergo J Int. 2014;23:282–319. EAACI 2022 update.
  4. NICE CKS. Allergic Rhinitis. cks.nice.org.uk. Reviewed 2023.
  5. Met Office. UK Pollen Forecast. metoffice.gov.uk. Accessed June 2026.

Page reviewed: June 2026 | London Allergy and Immunology Centre | privateallergy.uk

LAIC Main Menu